Author(s): DAUBIAN-NOSÉ, P., OYAMA, L.M., AQUINO, V., MINARI, A.L.A., DOS SANTOS, R.V.T., Institution: UNIVERSIDADE FEDERAL DE SÃO PAULO, Country: BRAZIL, Abstract-ID: 181

INTRODUCTION:
Physical exercise is a powerful physiological and biomolecular stimulator capable of promoting various physiological responses. The physiological responses arising from physical exercise depend on the training load imposed between each session. Studies carried out in humans and animal models prove that sleep restriction has significant consequences on physical performance.
METHODS:
Thirty 60-day-old male Wistar rats were used, divided into four groups (Sedentary Control (SC; N = 5), Sedentary Sleep Restriction (SRS; N = 5), Trained Control (TC; N = 10), and Trained Sleep Restriction (SRT; N = 10)). The animals were subjected to an initial maximal strength test, followed by a periodized strength training protocol lasting six weeks. Subsequently, the animals were subjected to a period of six hours of sleep restriction, with reassessment of the maximum strength test.
RESULTS:
The present research found an increase in the total body mass of all animals at the end of the six weeks of study. Six hours of sleep restriction was able to reduce the strength capacity of the TRS group by 18.4% compared to the TC group. There were no significant differences in glycogen values between the experimental groups for either the plantaris muscle or the soleus muscle. There was no significant difference in CLOCK protein concentrations in the plantar and soleus muscles. The work also demonstrated a significant difference in 15 metabolites from the anaerobic glycolysis pathway through metabolomic analysis.
CONCLUSION:
We conclude that sleep restriction attenuates the performance of maximal strength capacity in trained animals, also demonstrating that the training process reduces the impact of sleep restriction on performance, altering several metabolites of the anaerobic glucose pathway.