Author(s): YU, C., NAN, L., LIHUA, W., JUN, Z., MINGMING, Y., KAIYUAN, Q., ANQI, L., XIN, Y., JIAOYANG, Z., HAILING, Z., JIE, C., DAN, W., Institution: SHANGHAI UNIVERSITY OF SPORT, Country: CHINA, Abstract-ID: 1536

INTRODUCTION:
Metformin is a conventional drug for the treatment of non-obese polycystic ovary syndrome (PCOS), but the clinical features of the disease vary in their manifestations, leading to variable therapeutic effects. Low percentage of skeletal muscle is one of the important mechanisms of insulin resistance in non-obese PCOS patients. Exercise has been considered by the medical community as an important means of treating PCOS, but effective exercise intervention for non-obese PCOS patients has not been demonstrated yet. PURPOSE: to compare the effect of resistance training and metformin in the treatment of non-obese patients with PCOS.
METHODS:
Twelve non-obese PCOS patients were enrolled in this study and randomized in experiment group (EG = 6, 28.2±1.7yrs, 158.0±4.1cm, 53.1±3.2kg) which underwent resistance training, and control group (CG = 6, 27.7±3.7yrs, 163.5±1.9cm, 58.2±5.9kg) which took metformin, for continuous 12 weeks. Skeletal muscle mass, body fat percentage, and testosterone were measured pre-and post-intervention. Data analysis was performed using repeated ANOVA.
RESULTS:
Significant interactions between time and group were noted for testosterone (F = 10.072, P = 0.010, η2p = 0.816), significant differences between time were noted for skeletal muscle mass (F = 6.398, P = 0.030, η2p = 0.627), body fat percentage (F = 5.784, P = 0.037, η2p = 0.584).
CONCLUSION:
Twelve weeks of resistance training is effective in improving blood indicators, skeletal muscle mass, and body fat percentage in non-obese PCOS, in addition to improving sex hormone levels associated with PCOS while developing strength.