Author(s): CELIE, B.M.I., FAORO, V., CARPENTIER, M., CALDERS, P., LAPAUW, B., Institution: UNIVERSITÉ LIBRE DE BRUXELLES, Country: BELGIUM, Abstract-ID: 2463

INTRODUCTION:
A large body of evidence exists on the beneficial effects of exercise on type 2 diabetes mellitus (T2DM) aetiology, pathogenesis and its micro- and macrovascular complications. Also, postprandial continuous exercise has been shown to acutely blunt glycaemia in both healthy persons and patients with T2DM. To our knowledge, however, there are no available data about the effects of fasted state exercise in T2DM. Considering this lack of knowledge and because there are no data available on the effects of an acute high intensity exercise bout (HIT) in T2DM patients, the aim of this study was to evaluate the effect of HIT on glucose, insulin and
NEFA concentration in fasted versus postprandial state in patients with pre-diabetes and T2DM.
METHODS:
Eleven adult overweight or obese males with prediabetes or T2DM, defined as an HbA1c ≥ 6.0 %, using metformine monotherapy (n=9) or diet/exercise (n=2) were included in this study and were tested three times. First, they performed an incremental exercise test until exhaustion on a cycle ergometer to evaluate maximal oxygen consumption (VO2max). The second and third test (cycling), consisted of 3 minutes warming up at 50W, followed by 20 minutes HIT (ten times: 60 seconds
at 80% of VO2max and 60 seconds at 50 Watt), finishing with 40 minutes recovery (including 3 minutes cooling down). Exercise tests were carried out in fasted or postprandial state (90 minutes after a standard meal (carbohydrates: 56%; fat: 22%; proteins: 22%)). Nutritional status was randomized. Glucose, insulin
and non-esterified fatty acids (NEFA) were measured before and after warming up, after 10, 20 minutes of HIT and 40 minutes recovery in a venous blood sample. Data are expressed as mean (SD). A Repeated measures ANOVA was executed with post hoc Sidak to evaluate interaction effects (time * condition) and time effects. Significance level was set at P<0,05.
RESULTS:
Patients had a mean age of 42 (5,6) years; a mean BMI of 31,9 (5,11) kg/m2, an HbA1c of 6,6 (0,49) % and a relative maximal oxygen uptake of 21,4 (5,33) ml/kg.min. Glucose and insulin concentration decreased significantly in postprandial state during HIT (P<0,05 versus pre-HIT), but remained stable in the fasting state. Resting NEFA concentrations were increased in the fasting versus the postprandial condition (P<0,05) and remained stable during HIT (P<0,05).
CONCLUSION:
Postprandial interval exercise possesses the ability to blunt postprandial glycaemia in patients with prediabetes and T2DM while NEFA concentrations are higher in the fasted state but remain stable during HIT.