Author(s): OLIVA, V., UKROPCOVÁ, B., UKROPEC, J., MEGO, M., CHOVANEC, M., FORIŠEK PAULOVÁ, P., SEDLIAK, M., Institution: COMENIUS UNIVERSITY IN BRATISLAVA, FACULTY OF PHYSICAL EDUCATION AND SPORT, Country: SLOVAKIA, Abstract-ID: 844

INTRODUCTION:
Testicular cancer (TC) is the most common type of malignancy in young adult males of European ancestry and the incidence is still increasing steadily (1). Multi-disciplinary care, including orchiectomy and cisplatin combination chemotherapy (CHT), have resulted in dramatic improvement in the cure rate for TC and nowadays is considered as one of the most curable malignancies (2, 3). However, platinum-based CHT is associated with toxic actions and dysfunctions in non-targeted tissues (4). Exercise seems to be promising as adjuvant therapy in reducing some of the toxic actions and dysfunctions in patients undergoing platinum-based CHT (2, 4, 5). This case report explored the effects of exercise intervention on body composition, muscle strength, power, muscle endurance and cardiorespiratory fitness (CRF) in TC patient during the treatment.
METHODS:
Patient (age 50 y., height 172 cm, body weight 85,2 kg, BMI 28,8 kg/m2) diagnosed with seminoma underwent orchiectomy and 4 cycles of etoposide, cisplatin CHT treatment. Supervised and home-based exercise intervention was implemented during the 11-week treatment period where strength and aerobic training was performed. Electrical bioimpedance (BF511, OMRON, Japan) was used to assess fat mass, visceral fat and lean mass. Maximum muscle strength was assessed using the hand grip dynamometer (CAMRY EH101, China). Linear position transducer (FitroDyne Premium, FiTRONiC s.r.o., Slovakia) was used to assess muscle power during the counter-movement jump. Compound exercises were used to assess muscle endurance of upper and lower body. CRF was assessed by modified 3-minutes Step test (“YMCA version”).
RESULTS:
After implementing exercise intervention during 12-week platinum-based CHT treatment period, we observed reduction in fat mass (-2,2%), visceral fat (-2,0) and increase in lean mass (+1,1%). Despite observing slight reduction in maximum muscle strength, there were slight increase in muscle power production (+0,3%) and large increases in muscle endurance of lower and upper body (+20%, +5,7%, respectively). There was also an improvement observed in CRF (+14,3%).
CONCLUSION:
Exercise intervention during anti-cancer treatment may have the potential to ameliorate and/or reverse some acute toxic effects in TC patients. Rationale exists for the promotion of exercise oncology research in this setting, in order to provide exercise recommendations for patients during the treatment.
The contribution was created with the support of APVV-19-0411.
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