Author(s): WANG, J.S., HSU, C., Institution: CHANG GUNG UNIVERSITY, Country: TAIWAN, Abstract-ID: 275

INTRODUCTION:
This study aimed to assess the left ventricular (LV) remodeling response and long-term survival after high-intensity interval training (HIIT) in patients with HF during a 10-year longitudinal follow-up.
METHODS:
Among 214 patients with HF receiving guideline-directed medical therapy, those who underwent an additional 36 sessions of aerobic exercise at alternating intensities of 80% and 40% peak oxygen consumption (VO2peak) were considered HIIT participants (n=96). HF patients who did not undergo HIIT were considered participants receiving guideline-directed medical therapy (n=118). VO2peak, serial LV geometry, and time to death were recorded.
RESULTS:
The 10-year survival was better for participants who underwent HIIT (80.3%) than for participants on guideline-directed medical therapy (68.6%) (P=0.044). An increased ̇VO2peak, decreased minute ventilation carbon dioxide production slope, and reduced LV end-diastolic diameter were protective factors against all-cause mortality (P<0.05). Causal mediation analysis showed a significant mediation path for LV end-diastolic diameter on the association between HIIT and 10-year mortality in all included patients with HF (P<0.001). HIIT also had a significant direct association with 10-year mortality in patients with HF (P=0.027).
CONCLUSION:
Reversal of LV remodeling after HIIT could be a significant mediating factor for long-term survival in patients with HF.