Author(s): CHEN, Y.C., HSU, C.1, TSENG, C.1, METCALFE, R.2, WANG, H.1, Institution: NATIONAL TAIWAN NORMAL UNIVERSITY, Country: TAIWAN, Abstract-ID: 1209

INTRODUCTION:
High-intensity interval exercise ameliorates the impairment of postprandial metabolic health (i.e., glucose control) that is observed after a night of sleep restriction (SR). However, it is unknown whether moderate-intensity aerobic exercise can elicit similar effects.
METHODS:
11 young healthy active males (age: 26 ± 2 yr; BMI: 22.8 ± 2.6 kg/m2) were recruited in a randomised repeated measures cross-over study with three trials: 1) normal sleep (8 h sleep opportunity, NS); 2) sleep restriction (3 h sleep opportunity, SR); and 3) sleep restriction with exercise (3 h sleep opportunity + 30 min brisk walking, SRE). After waking at 7 a.m., participants engaged in either 30 min of sedentary behaviours in the NS and SR trials, or 30 min brisk walking at 50% V̇O2max in the SRE. This was followed by a 2-h oral glucose tolerance test (OGTT), with blood (plasma) samples collected at baseline, immediately post-exercise (or sedentary), and then at 15-, 30-, 45-, 60-, 90-, and 120-min following glucose ingestion. The primary outcome was glucose total area under the curve (tAUC) over the 150-min sampling period, with insulin tAUC and the early (0-90 min) and late (90-150 min) phase glucose tAUC as secondary outcomes.
RESULTS:
tAUC for glucose was lower in the NS trial (924 [95% CI = 865, 982] mmol/L) compared to both SR (1012 [95% CI = 945, 1080] mmol/L, p = 0.018) and SRE trials (1006 [933, 1080] mmol/L, p = 0.002) and there was no difference between SR and SRE (p = 1.00). There were no differences in the early phase glucose tAUC0-90 between trials. tAUC90-150 for glucose was lower in NS compared to SR (p = 0.002), but there were no differences between NS and SRE (p = 0.076) or between SR and SRE (p = 0.639). The tAUC for insulin did not differ between trials (p = 0.472).
CONCLUSION:
Postprandial glycaemia during a 2-hour OGTT was impaired after a single night of SR in young healthy active males and this was not rescued by a single 30 min bout of brisk walking performed immediately prior to the OGTT.