Author(s): YANCHUN, L.1, MIN, W.2, XUEYIN, F.1, MENGRU, Z.1, NAN, L.1, YIGAO, W.1, Institution: BEIJING SPORT UNIVERSITY, Country: CHINA, Abstract-ID: 2125

INTRODUCTION:
This study focused on the phenotypic characteristics of youth with metabolically unhealthy obesity (MUO)and metabolically healthy obesity (MHO). It aimed to evaluate the metabolic characteristics of combined training modalities, resistance training followed by moderate-intensity continuous training (RT+MICT), on the transition from MUO to MHO in young adults.
METHODS:
This randomized clinical trial, conducted from September 2024 to November 2024, involved 50 obese college students (ages 18-25) from China Agricultural University in Beijing. Of these, 30 participants were classified as MUO, while 20 were classified as MHO based on their phenotypic characteristics. Participants underwent a combined intervention of resistance training and MICT (50-75% HRmax), which was performed twice a week for a duration of 8 weeks.
RESULTS:
There were 33 differential metabolites identified between MUO and MHO individuals prior to exercise intervention. After an 8-week combined exercise program, 52% of the MUO participants transitioned to the MHO state, while 20 MHO participants remained in the MHO state. RT+MICT intervention significantly improved body composition, with reductions in body weight, body mass index (BMI), and percent body fat (PBF). Regarding metabolic health indicators, blood pressure remained unchanged, whereas blood glucose levels decreased in both groups. Following the 8-week combined exercise, there were 374 differential metabolites observed in the MUO group transitioning to the MHO state, and 342 differential metabolites identified in the MHO group that remained in the MHO state. Key metabolic indicators related to the combined training modalities that facilitated the transition of MUO in youth included tetradecanedioic acid, 4-Ethylphenylsulfate, p-Cresol, p-Cresol sulfate, Cholic acid, 1,4-dihydroxyheptadec-16-en-2-yl acetate, 7a-Hydroxy-cholestene-3-one, and Hypocrellin A.
CONCLUSION:
Combined exercise intervention effectively improves the metabolic abnormalities associated with MUO and promote its transition to the MHO state.