Author(s): LIN, Y., HUANG, S., PENG, S., WANG, J., Institution: CHANG GUNG UNIVERSITY, Country: TAIWAN, Abstract-ID: 712

INTRODUCTION:
Mitochondrial bioenergetics of peripheral blood cells (PBMCs) contribute to immune function in patients with end-stage renal disease (ESRD). This study aimed to elucidate the effect of predialytic exercise training (PDET) on systemic aerobic capacity and PBMC mitochondrial bioenergetic efficiencies in ESRD patients.
METHODS:
Twenty ESRD patients performed PDET i.e., 24-week hospital-based exercise (cycling exercise at 50-60% peak workload for 30 minutes/day, 3 days/week) followed by 12-week home-based exercise (online instructions). Additionally, 20 age- and gender-matched healthy sedentary participants were recruited as a healthy sedentary (HS) group. Peak oxygen consumption (VO2peak), mitochondrial oxidative phosphorylation (OXPHOS), electron transport capacity (ETC), and bioenergetic health index (BHI) in PBMCs were measured using automatic gas analyzer and high-resolution respirometer, respectively.
RESULTS:
The ESRD group exhibited (i) lower peak workload and VO2peak, (ii) fewer lymphocyte counts and higher neutrophil-to-lymphocyte ratio (NLR), myeloperoxidase, and Interleukin-6 in blood, and (iii) inferior mitochondrial OXPHOS, ETC, and BHI in PBMCs, compared to the HS group. However, PDET significantly (i) elevated peak workload and VO2peak, (ii) increased lymphocyte count and depressed NLR, myeloperoxidase, and Interleukin-6 in blood, (iii) enhanced mitochondrial OXPHOS, ETC, and BHI in PBMCs, and (iv) elevated the Short Form-36 physical and mental components and Kidney Disease Quality of Life-36 scores. Moreover, VO2peak was positively correlated to mitochondrial OXPHOS, ETC, and BHI in PBMCs.
CONCLUSION:
PDET improves systemic aerobic capacity in ESRD patients. Moreover, this exercise regimen effectively enhances mitochondrial bioenergetics efficiencies through increasing OXPHOS and ETC in PBMCs, whose responses are associated with VO2peak in ESRD patients.