Scientific Programme
Physiology & Nutrition
IS-PN03 - New Frontiers in Exogenous Ketone Supplement Research – Implications for Performance, Recovery, and Health Across the Lifespan
Date: 08.07.2026, Time: 09:30 - 10:45, Session Room: Auditorium C (STCC)
Description
Chair(s)
Nir Eynon
Monash University, Australian Regenerative Medicine Institute
Australia
Speaker A
Nir Eynon
Monash University, Australian Regenerative Medicine Institute
Australia
Read CVECSS Rimini 2025: IS-PN03
Multi-OMIC approach to identify exercise & ageing biomarkers in humans
Ageing represents an important health and economic burden on society. Approximately 15% of the world population are over 65, a proportion expected to rise to 22.5% by 2050. Sedentary behaviour and lack of physical activity accelerate the widespread cellular and molecular changes induced by ageing, resulting in the increased prevalence of many chronic diseases. Epigenetics (particularly DNA methylation) is one of the hallmarks of ageing. The epigenome is affecting gene & protein expression, and is particularly sensitive to exercise, and exercise training programs caused widespread DNA methylation shifts in genes that are relevant for skeletal muscle health, and ageing. My research group focuses on the development of novel, cross-tissue molecular approaches to identify sex-specific healthy ageing and exercise-related marks in humans (1-3). This approach will provide a greater understanding of the multiplicity and complexity of the cellular networks involved in exercise responses and strong translational path. The Gene SMART study, led by our group, is the first of its kind to comprehensively assess genetic and epigenetic markers that contribute to muscle health pre-and-post intense exercise (total of ~2500 human muscle & blood samples at various exercise points). Using data mining, and unique bioinformatics approaches we combined the Gene SMART cohort, data sets from international collaborators and open access datasets to perform a powerful Multi-OMIC molecular analyses to uncover robust marks of exercise & ageing in males and females. In my presentation, I will discuss some of the recent research coming from my group on how exercise mitigate the ageing molecular responses. References: 1. Voisin S, Seale K, Jacques…. Sharples AP, & Nir Eynon. Exercise is associated with younger methylome and transcriptome profiles in human muscle. Aging Cell 2: e13859, 2024. 2. Voisin S…, Horvath S, & Eynon N. Meta-analysis of genome-wide DNA methylation and integrative OMICs of age in human skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle 12; 4:1064-1078, 2021. 3. Landen… Lamon & Eynon. Sex differences in muscle protein expression and DNA methylation in response to exercise training. Biol Sex Differ.5;14(1):56, 2023.
The molecular symphony of acute exercise: multi-omic responses across tissues
Multi-omic assays offer unparalleled opportunities to study how different tissues coordinately respond to various exercise modalities at the molecular level. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to create a comprehensive molecular map of these responses to exercise and training. In this symposium organized by Dr. Nir Eynon, Dr. Lindholm will present multi-omic data from the first MoTrPAC human cohort—sedentary adults who completed an acute bout of either endurance or resistance exercise, with comparison to non-exercise controls to account for e.g. circadian effects. The findings reveal global molecular responses across skeletal muscle, adipose tissue, and blood, with integration across multiple dimensions, including tissue type, exercise modality, time point and omic level. These analyses identify key molecular pathways and central regulators while revealing novel exerkines that may mediate exercise's multi-organ effects. To complement the human data, Dr. Lindholm will also present multi-omic responses to acute endurance exercise in rats, providing insights into organs that cannot be sampled in humans.
Speaker C
Kevin Murach
University of Arkansas, Health, Human Performance, and Recreation
United States
Read CVECSS Rimini 2025: IS-PN03
The Multi-Omic Signatures of Hypertrophic Exercise Adaptation
The Molecular Muscle Mass Regulation (M3R) Laboratory (PI: Murach) uses human muscle samples, primary cell culture, genetically modified mouse models, single cell/ nucleus omics, and computation to understand the molecular cues that drive exercise adaptations and aging, and the interaction between the two. Work from the lab has shown how specific exercise-induced transcription factors such as MYC can drive muscle growth in skeletal muscle, how myonuclear epigenetics contribute to “muscle memory”, and how muscle stem cells (satellite cells) affect hypertrophic adaptation throughout the lifespan. This talk will focus on how multi-omic approaches (including epigenomics, transcriptomics, and proteomics) applied to unique genetically modified mouse models and exercise strategies reveals the mechanisms of muscle adaptation to exercise throughout the lifespan. Specific emphasis will be placed on multi-omic integration in preclinical models of muscular exercise as well as a focus on molecular responses in muscle fiber nuclei (myonuclei) and satellite cells to mechanical loading.