ECSS Paris 2023: OP-MH02
INTRODUCTION: The Sail4Parkinson (S4P) is a one-week adapted physical activity intervention program for persons with Parkinson’s disease (PD), with the mission of combining physical training of water sports with the physical, emotional, and psychological stimulus that comes from contact with the sea and the lands around. The aim of this study was to investigate the acute effects of different innovative aquatic and mind-body activities on clinical, psychosocial, and motor symptoms in persons with PD after the S4P project week. METHODS: Thirteen subjects (6M:7F, median Hoehn-Yahr: 2; range: 2-3) volunteered to participate in the one-week S4P project. From the second to the sixth day, several aquatic activities (i.e., sailing, surfing, paddling) were performed during the day after a daily session of mindfulness at sunrise, yoga, or tai chi at sunset. On the other hand, during the first (PRE) and the last (POST) day, main general and PD outcomes (i.e., anthropometrics, body composition, balance, muscular strength, upper-limb flexibility, heart rate variability, and quality of life) were assessed. RESULTS: Repeated-measures ANOVA and adjusted post-hoc comparisons revealed significant changes in Fat-Free Mass (PRE-POST change: +1.80%; p=0.049) and Skeletal Muscle Mass (PRE-POST change: +2.69%; p=0.044). A significant reduction was observed in the time to complete the Five Times Sit-to-Stand Test (PRE-POST change: -14.75%; p=0.002) and the time to complete the Timed Up and Go Test (PRE-POST change: -15.93%; p=0.005). Balance evaluations showed a significant reduction in mediolateral oscillation length (PRE-POST change: -39.18%; p=0.020) and mediolateral oscillation velocity (PRE-POST change: -39.18%; p=0.020), both performed with open eyes. Non-parametric test run on clinical scores revealed a significant reduction in the Apathy Evaluation Scale (PRE-POST change: -20.61%; p=0.028). CONCLUSION: Despite the short-term intervention, the S4P project demonstrated several beneficial effects on both motor and non-motor PD symptoms, reducing fall risk and apathy. Preliminary data suggest that these innovative activities may be valuable for this population, particularly in enhancing psychosocial well-being through teamwork and blue environmental stimuli. Therefore, promoting these activities to be repeated twice per year, for instance, and promoting similar training at home, could become an effective strategy for improving the management of PD and the overall quality of life of these persons.
Read CV Davide NataleECSS Paris 2023: OP-MH02
INTRODUCTION: Cancer treatments and a sedentary lifestyle increase the risk of type 2 diabetes (T2D) in breast cancer survivors (BCS). Lifestyle Interventions (LI), which provide physical activity (PA) and dietary guidance, may be an effective adjunctive treatment for BCS, but the impact of exercise training on glucose homeostasis remains inconclusive [1]. This study aimed to compare glucose variability indices between two groups of BCS participating in the MoviS clinical trial [2]. METHODS: BCS patients with metabolic syndrome (n=27, 52.3±8.6 yrs [mean ± SD]) were randomized into a control group (CG, n=12) and an intervention group (IG, n=15). All patients received recommendations on PA and Mediterranean diet before beginning a 12-week trial, during which they kept a daily log for PA. IG patients also underwent a 3-time-a-week aerobic training program with progressive increases in exercise intensity (40-70% of heart rate reserve) and duration (20-60 min). Before (T0) and after (T1) the trial, participants’ body composition (BIA), cardiorespiratory fitness (GXT estimated VO2max), and cardiometabolic profile (routine laboratory parameters) were assessed along with glycemic variability (flash glucose monitor - FGM), which was assessed over 14 days (12±1.8 days) after T0 and before T1. Glycemic variability was calculated with the EasyGV software (v.9.0.R2). Statistical significance (α=0.05) was determined using a Repeated Measures GLM (SPSS software v.17). RESULTS: At T1, both groups significantly improved fat mass (CG -1.0%; IG -3.8%), triglycerides (CG -4.2% IG: -15.9%), insulin levels (CG -14.1%; IG -15.6%), and HOMA-IR (CG -13.7%; IG -16.3%). Cardiorespiratory fitness (GC +3.1%; IG +16.4%) and between-day glycemic variability index (CG +12.5%; IG -3.6%) significantly changed in both groups and resulted significantly better in the IG compared to the CG. Time spent within the normal glucose range (CG -11.0%; IG -1.8%) and with a glycemia above 180 mg/dL (CG: +1.1%; IG +0.7%) worsened at T1. Although time x group interactions were, respectively, nonsignificant and barely significant, CG changes were broader. CONCLUSION: The LI program improved body composition and cardiometabolic health in BCS patients at high risk for T2D, with an overall, although nonsignificant, lower effectiveness in CG than in IG patients. Since aerobic training effectively increased cardiorespiratory fitness solely in the IG and given that selected parameters of the glycemic profile improved significantly more in the IG than in the CG group, improvements seem to be attributable to the supervised exercise as an adjunctive effect over guidance alone. However, other glycemic parameters did not improve in IG patients. Thus, further research is needed to support the role of aerobic training in improving glycemic profile in BCS at high risk of diabetes. 1. Viskochil, R. et al., J Clin Endocrinol Metab 2020. 2. Natalucci, V. et al. Trials 2023. We thank Innovation Zed Ltd. for FGM devices and PNRR MUR ECS_00000041-VITALITY.
Read CV Marta ImperioECSS Paris 2023: OP-MH02
INTRODUCTION: Pediatric cancers represent 2270 new cases each year in France [1]. The disease and its treatments cause significant symptoms (e.g., fatigue, reduced quality of life). Exercise is recognized as a non-pharmacological intervention in pediatric oncology to mitigate the numerous side effects [1]. However, exercise is often restricted by the constraints of cancer treatments and hospitalization (e.g., isolation in sterile room, amputation, fatigue) [1]. Virtual Reality-based exergames (VRE) have shown promise in promoting physical activity [2] but their application in pediatric oncology remains underexplored. This study aims to assess the feasibility of a VRE for pediatric cancer patients undergoing treatment in a hospital setting. Specifically, it evaluates compliance and acceptance while assessing exercise intensity to ensure alignment with WHO recommendations (> 3 MET). METHODS: Thirteen pediatric cancer patients (diagnosed with leukemia or sarcoma) participated in VRE sessions proposed four times during afternoons per week over a two-month period in the pediatric oncology unit of Sud Hospital, Rennes. The VRE used in this study was developed by the lab team and designed to resemble Beat Saber with additional adaptability options. A total of 131 sessions were analyzed to assess compliance rates (number of sessions offered relative to those proposed), Technology Acceptance Model [3] was used to assess acceptance and exercise intensity was assessed with Lee et al. model [4]. RESULTS: The VRE showed a solid compliance rate of 68%, with individual variability influenced by factors such as age, prior VR experience, and intended use. Acceptance was high, with a strong user experience rating (5.36/6 ±0.51), and no serious side effects were reported. The average exercise intensity per child reached 4.44 ± 1.91 MET, exceeding the moderate-intensity threshold. CONCLUSION: The key findings indicate that this VRE practice is feasible and well-accepted in a pediatric oncology setting, providing effective moderate-to-vigorous exercise levels in accordance with WHO recommendations while ensuring patient engagement, despite individual differences. Expanding the variety of VR content could better cater to the needs of diverse age groups, particularly adolescents. Furthermore, integrating autonomous adaptation based on physiological and kinematic data could improve the programs effectiveness and engagement by targeting specific intensity levels. References: [1] INCa. Bénéfices de l’activité physique pendant et après cancer – Des Connaissances aux repères pratiques - Ref: ETACTPHYRA17, 2017. 1 [2] R. Peyrachon and A. Rebillard. JMIR cancer, 9:e45037, May 2023. [3] Sagnier, C. et al. International Journal of Human–Computer Interaction 36, no 11 (2020): 993 1007. [4] Lee, Mihyun et al., Sustainability 13, no 9 (2021).
Read CV Jos DeforgesECSS Paris 2023: OP-MH02