Abstract details
| Abstract-ID: | 1935 |
| Title of the paper: | Effects of a 12-week home-based physical activity program on insulin-like growth factor axis in middle-aged breast cancer survivors |
| Authors: | Kim, N., Park, J. |
| Institution: | Keimyung University College of Nursing |
| Department: | Department of Basic Nursing Science |
| Country: | Korea, South |
| Abstract text | INTRODUCTION: Physical activity may reduce the risk of breast cancer development and recurrence by influencing the insulin-like growth factor (IGF) signaling pathway. Activation or increase of the IGF signaling system is generally considered as a mechanism driving breast cancer risk. However, evidence strongly supporting the biological plausibility of the physical activity-IGF axis-breast cancer pathway is still lacking. Therefore, the purpose of this study was to examine the effects of a home-based physical activity program on IGF axis, including IGF-1 and IGF binding protein-3 (IGFBP-3) in middle-aged breast cancer survivors. METHODS: In this study, a non-equivalent control group pretest-posttest design was used. Community-dwelling middle-aged breast cancer survivors were eligible. Data from 28 participants, comprising 13 in the intervention group and 15 in the control group, were analyzed. The intervention group was motivated and monitored to increase physical activity in daily life through group education, individual counseling, and telephone coaching for 12 weeks. The control group was instructed to continue their daily physical activity. IGF axis parameters (IGF-1 and IGFBP-3) were measured using participants blood samples. Data analysis were performed using SPSS version 19.0, including descriptive analysis, Chi-squared tests, Fisher’s exact tests, and Mann-Whitney U tests. RESULTS: After a 12-week home-based physical activity program, the IGF-1 level in the intervention group decreased by 18.54 ng/mL compared to before the intervention., and in the control group, it decreased by 3.74 ng/mL compared to before the intervention, showing a significantly difference between the two groups (F=4.92, p=.038). In addition, the IGFBP-3 level was in the intervention group decreased by 1499.47 ng/mL compared to before the intervention., and in the control group, it decreased by 307.24 ng/mL compared to before the intervention, showing a significantly difference between the two groups (F=14.28, p=.001). CONCLUSION: These findings showed that a 12-week home-based program for promoting physical activity was effective in reducing IGF-1 and IFGBP-3 parameter. Therefore, in order to reduce cancer recurrence in middle-aged breast cancer survivors, it is necessary to encourage increased physical activity in daily life and further help them make physical activity a habit. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science and ICT) (No. 2020R1A2C1006590). |
| Topic: | Health and Fitness |
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