Abstract details
| Abstract-ID: | 1905 |
| Title of the paper: | Association between Decorin Levels and Cardiometabolic Function after Endurance Exercise |
| Authors: | Cury-Boaventura, M.F.1, Fontes-Junior, A.1, de Oliveira, L.1, de Sousa, C.1, Sierra, A.2 |
| Institution: | 1Cruzeiro do Sul University, 2University of Sao Paulo |
| Department: | 1Interdisciplinary Post-graduate Program in Health Sciences, 2School of Physical Education and Sport |
| Country: | Brazil |
| Abstract text | INTRODUCTION: Decorin is a member of the small leucine-rich proteoglycan family of extracellular matrix proteins that interact with collagen fibers secreted from myotubes in response to exercise. It has been reported to modulate human skeletal muscle cell proliferation and differentiation and directly inhibits myostatin. Furthermore, decorin seems to act on lipid metabolism, angiogenesis, or vascular homeostasis in adipose and skeletal tissues. The increase of decorin levels after exercise has been reported, as well as its effects in skeletal muscle; however, the involvement of decorin in cardiometabolic adaptations induced by endurance exercise has not yet been investigated. We investigated the association of decorin levels with cardiometabolic function before and after endurance exercise. METHODS: Fifty-six Brazilian male amateur marathon finishers, aged 30 to 55 years, participated in this study. Blood samples were collected, and plasma levels of decorin were determined using enzyme-linked immunosorbent assay before and after the Sao Paulo International Marathon. Cardiopulmonary exercise test (CPET) was performed using a treadmill protocol (TEB Apex 200, TEB, São Paulo, Brazil) before and after the race. The test was performed at a 1% fixed slope, and speed began at 8 km/h, increasing 1 km/h per minute until maximal exhaustion of the runner. Expired gas analysis was performed using a breath-by-breath system (Quark CPET, Cosmed, Rome, Italy). Correlations between decorin and CPET parameters were performed by Spearman test. Statistical significance was accepted at a level of p < 0.05 in all analyses. RESULTS: Before the race, decorin levels were negatively correlated with Speed (km/h, r = -0.28, p = 0.026), VO2 consumption (mL/kg/min, r = -0.43, p < 0.0004) in anaerobic threshold (AT), and OUES in CPET before the competition. However, decorin levels immediately after the race were positively correlated with Speed (km/h), VO2 consumption (mL/kg/min), VE/VCO2, fat oxidation (%) in AT (r = 0.49, p = 0.0001, r = 0.36, p = 0.013, r = 0.47, p = 0.0002, r = 0.27, p = 0.045, respectively), RC (r = 0.52, p < 0.0001, r = 0.36, p = 0.009, r = 0.55, p < 0.0001, r = 0.48, p = 0.0002), and Peak (r = 0.54, p < 0.0001, r = 0.31, p = 0.033, r = 0.55, p < 0.0001, r = 0.39, p = 0.002) as well as Oxygen Uptake Efficiency Slope (OUES, r = 0.34, p = 0.010) in CPET after the race. In addition, decorin levels were negatively correlated with the relative quotient (RQ), PETCO2, and carbohydrate oxidation (%) in CPET after the race in AT (r = -0.30, p = 0.024, r = -0.56, p < 0.0001, r = -0.32, p = 0.014, respectively), RC (r = -0.65, p < 0.0001, r = -0.60, p < 0.0001, r = -0.47, p = 0.0002), and Peak (r = -0.63, p < 0.0001, r = -0.59, p < 0.0001, r = -0.40, p = 0.0025). CONCLUSION: Our findings demonstrate an association between decorin levels and cardiometabolic function after endurance exercise. We suggest that decorin may be an important myokine involved in cardiometabolic adaptations induced by endurance exercise. |
| Topic: | Physiology |
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