Abstract details
| Abstract-ID: | 1898 |
| Title of the paper: | Effects of Pyrroloquinoline Quinone (PQQ) supplementation on aerobic exercise performance in non-endurance-trained athletes |
| Authors: | Charrier, D., Simoni, L., Alfier, A., Slanzi, G., Moro, T., Paoli, A. |
| Institution: | University of Padova |
| Department: | Biomedical Sciences |
| Country: | Italy |
| Abstract text | INTRODUCTION: Pyrroloquinoline quinone (PQQ) is a newly compound acting on redox modulation, cellular energy metabolism, and mitochondrial biogenesis. Recent evidence indicates that supplementing with PQQ can enhance mitochondrial biogenesis by increasing PGC-1alfa protein. Increasing mitochondrial biogenesis can enhance the maximum capability of skeletal muscles to generate ATP through oxidative phosphorylation, positively impacting the ability to utilize fatty acids during moderate-intensity exercise and so improving aerobic performance. The aim of this study was to examine the effects of PQQ supplementation on body composition, endurance performance, and mitochondrial activity in a group of non-endurance-trained athletes (basketball players). METHODS: Twenty basketball players (10 males and 10 females, age: 22.9±2.36, VO2max: 42.9±6.49 mL/min/Kg) were randomized to consume a supplement containing 20 mg/day of PQQ or placebo (PLA) during a six-week intervention. Subjects were encouraged to maintain their usual diet and training schedule. Body composition was assessed by dual-energy-x-ray-absorptiometry and bioimpedance analysis. Aerobic exercise performance was evaluated through a graded exercise protocol (six 5-minutes steps followed by n 2-minutes steps until exhaustion; the initial workload was 60 watts and increased by 35 watts at the end of each step) performed on a cycle ergometer. VO2, respiratory quotient (RQ), energy derived from carbohydrates (kcal/day) and fats (kcal/day) were assessed by gas analysis system. Capillary blood lactate samples were collected at the end of each step. Blood and urine samples were also collected, and proteomics analysis will be performed. RESULTS: Body composition nor aerobic performance were altered by the intervention. Although a reduction in RQ and carbohydrate consumption was graphically visible, statistical significance was not achieved, probably due to a high interindividual variability of response in the PQQ group. We indeed identified a group of responders (5 subjects) who significantly (p=0.02) reduced their RQ, as well as carbohydrate consumption, after supplementation compared to (5 subjects) non-responders. In particular, a significant reduction was observed during the third step (10-15min, p=0.002) and the fourth step (15-20min, p=0.004). CONCLUSION: Supplementation of PQQ does not appear to elicit any ergogenic effects regarding aerobic performance or body composition in a group of not endurance athletes. However, we have observed a significant range of responses in the PQQ group, which deserve further investigation. Subsequent proteome analysis may contribute to a more comprehensive understanding of the relationship between PQQ supplementation and the metabolic responses. |
| Topic: | Nutrition |
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