Abstract details
| Abstract-ID: | 1887 |
| Title of the paper: | Acute ketone monoester intake improves blood flow regulation in females with polycystic ovary syndrome |
| Authors: | Berbrier, D., Huckins, W., Delage, S.I., Van Berkel, E.K., Hannaian, S.J., Churchward-Venne, T.A., Usselman, C.W. |
| Institution: | McGill University |
| Department: | Kinesiology and Physical Education |
| Country: | Canada |
| Abstract text | INTRODUCTION: Polycystic ovary syndrome (PCOS) is an endocrinopathy associated with vascular dysfunction and insulin resistance, resulting in an elevated cardiovascular disease risk. Exogenous ketone supplementation can decrease blood glucose concentration and has been suggested to improve vascular function via improvements in blood flow in individuals predisposed to cardiovascular disease, but has yet to be assessed in females with PCOS. Therefore, we tested the hypothesis that acute ketone monoester (KME) ingestion would improve glucose-stimulated increases in blood flow in healthy lean females with PCOS. METHODS: Ten otherwise healthy females with PCOS (age: 27 ± 5 yr, body mass index: 23.8 ± 2.7 kg/m2, physical activity: 229 ± 111 min/week), participated in a randomized, double-blind, placebo controlled, acute crossover intervention study. In the overnight post-absorptive state, participants consumed the KME (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (0.45 ml/kg body mass) or a taste-matched non-caloric placebo 30 minutes prior to completing a 2-hour 75g oral glucose tolerance test (OGTT). Venous blood samples to assess beta-hydroxybutyrate (ß-OHB) concentrations were collected at baseline, at 30-min after KME intake and concurrent with OGTT ingestion (time point 0), and at 15, 30, 60, 90, and 120-min post-OGTT. Blood pressure (measured via finger photoplethysmography calibrated to manual sphygmomanometry) was continuously recorded throughout the OGTT. Leg blood flow (LBF; duplex ultrasound, superficial femoral artery) and femoral vascular conductance (FVC; LBF/mean arterial pressure) were assessed at baseline and at 0, 15, 30, 60, 90, 120-min post-OGTT. RESULTS: In the placebo trial, blood ß-OHB concentration, LBF, and FVC remained unchanged throughout the OGTT (main effects of time all P>0.05). In contrast, KME intake significantly elevated blood ß-OHB concentration, reaching 3.1 ± 0.8 mM within 30 minutes and remained elevated throughout the OGTT (main effect of time P<0.01). Additionally, KME ingestion led to a sustained increase in both LBF and FVC across all OGTT timepoints (main effects of time all P<0.01). Notably, peak OGTT-induced increases in LBF (+171 ± 50 vs. +27 ± 14 mL/min, P<0.01) and FVC (+1.9 ± 0.7 vs. +0.5 ± 0.3 mL/min/mmHg, P<0.01) were greater in the KME compared to placebo trial. CONCLUSION: These findings suggest that acute KME ingestion enhances glucose-stimulated vascular function in lean females with PCOS. Notably, this lean, physically active phenotype of PCOS is frequently overlooked in both research and clinical interventions, despite evidence suggesting it may represent the most severe form of the disorder. Given the heightened cardiovascular disease risk in this cohort, KME supplements may offer a potential therapeutic strategy in the managements and prevention of cardiometabolic disease risk in females with PCOS. |
| Topic: | Health and Fitness |
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